COVID-19

Evidence Synthesis Ireland, Cochrane Ireland and the HRB Trials Methodology Research Network have refocused their collective resources on prioritised COVID-19 activities to support healthcare policy and practice decision making in Ireland and beyond. The group, called the Emergency Evidence Response Service, is working in collaboration with the NUI Galway Library and colleagues throughout the University (including the Health Behaviour Change Research Group) and broader research community, and are working quickly and flexibly on prioritised questions from the World Health Organisation (WHO), Cochrane, Campbell UK & Ireland, governments, EPPI-Centre (London), the Centre for Evidence Based Medicine (CEBM, Oxford) and others.

The methodological expertise in the group includes evidence synthesis across qualitative, quantitative, mixed methods and meta-analysis, randomised controlled trials, trial methodology, core outcome set development and outcome reporting, prioritisation, psychology, behaviour science, behaviour change, implementation science, open science, information searching, communication and dissemination.

Health claims – fact checked

• iHealthFacts.ie is a platform where the public can submit health claims and our team work to answer the claim by searching for and assessing the available evidence.
• Prioritised health claims are assessed with an established process by searching for high-quality evidence to support or refute the claim. The prepared responses are reviewed by a team of Evidence Advisors and by a panel of Public and Patient Advisors.
• 19 COVID-related health claims have been fact-checked to date
• Non-COVID health claims can now be submitted
• Follow iHealthFacts on Twitter and Facebook

Publications

Houghton et al 2020, Cochrane qualitative rapid review (21 April 2020)

• • Full review: Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis
  • Cochrane EPOC summary – implementation considerations
  • ESI – one page summary
  • Cochrane podcast and clinical answers

Fast-tracked prioritised update of a Cochrane review on PPE (Verbeek et al)

• “Personal protective equipment for preventing highly infectious diseases due to contact with contaminated body fluids in health care staff” available here.
• Cochrane summary and ESI one-page summary and an animated podcast

• Blogpost on Evidently Cochrane on the above two reviews, on PPE for healthcare workers

Noone et al, Cochrane Rapid Review, Video calls for reducing social isolation and loneliness in older people 21 May 2020

Series of rapid reviews on PPE for the Centre for Evidence Based Medicine in Oxford

Mapping of evidence

• Participating in the Steering Group and in mapping of a living mapping of studies of COVID-19 (@COVIDNMA).
  • Contains living systematic reviews on pharmacological and non-pharmacological treatments, preventive treatments and rehabilitation
  • The WHO are now using https://covid-nma.com/as a primary source of evidence on treatments for the prevention and treatment of COVID-19
  • You can filter studies by type of pharmacological treatment, registration date, study aim, severity scale and an interactive map of clinical trials per country.
  • Protocol published here
• Cochrane Ireland, France, Austria, Germany and IQWiG, calling for transparency of COVID19 studies, issued an open letter to the European Medicines Agency to make clinical data from trials of COVID-19 medicines and vaccines available at the time of marketing authorisation.

Evidence, collaboration and co-ordination

• We placed seven volunteers for Evidence Aid, an international humanitarian organisation, who contributed to a large effort toward producing and translating over 200 evidence summaries within the categories of clinical characterisation and management, health systems and services, infection prevention and control.
• We are part of a global network of over 75 researchers co-ordinating evidence synthesis called COVID-END which includes a guide to COVID-19 evidence sources. Also we are members of the International Cochrane COVID-19 Executive Response Team and the Evidence Collaborative for COVID-19 network with the WHO.
• HRB-TMRN are part of a Study Within A Trial (SWAT) prioritisation post COVID-19 group to establish what SWATs should be prioritised to deal with delays and issues with recruitment and retention to trials (in collaboration with the University of Aberdeen)